Sterile or nonantibiotic-responsive pustular dermatitis and canine leishmaniosis: a 14 case series description and a statistical association study on 2420 cases.

Background - No striking clinical and histopathological features of pustular dermatitis (PustD) in dogs suffering from canine leishmaniosis (CanL) have been identified; an association between CanL and PustD has not been demonstrated. Objectives - To characterize a series of dogs affected by CanL and pruritic PustD, and to evaluate a possible association between the two conditions. Conclusions - An association exists between PustD and CanL. At least in Leishmania-endemic areas, CanL should be ruled out before attempting an immunosuppressive treatment in dogs with PustD with the aforementioned characteristics. Staging of CanL through diagnostic procedures besides immunohistochemistry and PCR is recommended. Anti-leishmania treatment and short-to-medium courses of low-dose anti-inflammatory or immunomodulatory drugs are effective in controlling the clinical signs of PustD.