Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.

Juan ShiQun-Hui WangXiang WeiBo HuoJian-Nan YeXin YiXin FengZe-Min FangDing-Sheng JiangMing-Jia Ma

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Thus, our results revealed that P300 deficiency or inactivation facilitated CD- and IKE-induced VSMC ferroptosis by activating the HIF-1α/HMOX1 axis, which may contribute to the development of diseases related to VSMC ferroptosis.

Keyphrases

vascular smooth muscle cells
cell death
signaling pathway
angiotensin ii
endothelial cells
high glucose
replacement therapy
dna methylation
diabetic rats
drug induced
oxidative stress
gene expression
nk cells