Transcriptional profiling demonstrates altered characteristics of CD8 + cytotoxic T-cells and regulatory T-cells in TP53-mutated acute myeloid leukemia.
Milad AbolhalajViktor SincicHenrik LilljebjörnCarl SandénAlar AabKarin HägerbrandPeter EllmarkCarl A K BorrebaeckThoas FioretosKristina LundbergPublished in: Cancer medicine (2022)
The results provide insights on mechanisms underlying the inadequate immune response to leukemic cells in TP53-mutated AML and open up for further exploration toward novel treatment regimens for these patients.
Keyphrases
- acute myeloid leukemia
- regulatory t cells
- immune response
- end stage renal disease
- dendritic cells
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- allogeneic hematopoietic stem cell transplantation
- ejection fraction
- gene expression
- peritoneal dialysis
- prognostic factors
- transcription factor
- cell cycle arrest
- inflammatory response
- cell proliferation
- cell death
- endoplasmic reticulum stress
- combination therapy
- replacement therapy
- heat shock protein