Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy.
Jacqueline M CohenSilje AlvestadElizabeth A SuarezAndrea L SchafferRandi M SelmerAlys HavardBrian T BatemanCarolyn E CestaHelga ZoegaIngvild OdsbuKrista F HuybrechtsLars Jøran KjerpesethLoreen StraubMaarit K LeinonenMarte Helene BjørkMette NørgaardGissler MikaSinna Pilgaard UlrichsenSonia Hernandez-DiazTorbjörn TomsonKari FuruPublished in: Neurology (2023)
This study provides Class II evidence that in people with epilepsy treated in the first trimester of pregnancy, the risk of major congenital malformations is lower with lamotrigine-levetiracetam duotherapy than with valproate alone, but similar with lamotrigine-topiramate.