Autologous CD19- targeting CAR T cells in refractory juvenile dermatomyositis.

Rebecca NicolaiPietro MerliPatricia Moran AlvarezClaudia BracagliaFrancesca Del BufaloEmiliano MarascoIvan CaielloGiusi PrencipeMattia AlgeriMaria G CefaloMarco BecilliConcetta QuintarelliMatilde SinibaldiLinda HanssensFabrizio De BenedettiFranco Locatelli

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

This JDM patient with severe chronic disease, refractory to multiple treatments, achieved sustained B-cell depletion and ongoing immunosuppressive drug-free clinical and radiological improvement eight months after a single infusion of anti-CD19 CAR T cells.

Keyphrases

induced apoptosis
cell cycle arrest
low dose
nk cells
case report
bone marrow
interstitial lung disease
early onset
cell therapy
drug induced
cancer therapy
emergency department
endoplasmic reticulum stress
signaling pathway
drug delivery
platelet rich plasma
disease activity
adverse drug
cell proliferation