Markers of epithelial-to-mesenchymal transition reflect tumor biology according to patient age and Gleason score in prostate cancer.

Dorota JędroszkaMagdalena Julita OrzechowskaRaneem HamouzKarolina GórniakAndrzej K Bednarek

Published in: PloS one (2017)

Our major observation is that prostate cancer from patients under 50 years old compared to older ones has entirely different EMT gene expression profiles showing potentially more aggressive invasive phenotype, despite Gleason score classification.

Keyphrases

prostate cancer
radical prostatectomy
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
deep learning
machine learning
epithelial mesenchymal transition
prognostic factors
physical activity
case report
genome wide
gene expression
patient reported outcomes
patient reported