Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury.
Yongmei ZhaoMao DingFeng YanJie YinWenjuan ShiNan YangHaiping ZhaoYalan FangYuyou HuangYangmin ZhengXueqi YangWei LiXun-Ming JiYu-Min LuoPublished in: CNS neuroscience & therapeutics (2022)
RIPC ameliorates the induction of the JAK2/STAT3 pathway and cell cycle regulators cyclin D1 and CDK6 by MCAO, and this net inhibition of cell cycle re-entry by RIPC is associated with downregulation of STAT3 phosphorylation.