Precision Medicine in Pediatric Neurooncology: A Review.
Aaron Y MochizukiIsaura M FrostMelina B MastrodimosAshley S PlantAnthony C WangTheodore B MooreRobert M PrinsPaul S WeissSteven J JonasPublished in: ACS chemical neuroscience (2017)
Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects. Here, we review emerging trends and the current literature that have guided the development of new molecularly based classification schemas, promising diagnostic techniques, targeted therapies, and delivery platforms for the treatment of pediatric central nervous system tumors.
Keyphrases
- mental health
- healthcare
- public health
- induced apoptosis
- end stage renal disease
- machine learning
- ejection fraction
- newly diagnosed
- traumatic brain injury
- prognostic factors
- oxidative stress
- young adults
- blood pressure
- bipolar disorder
- cell proliferation
- health information
- body composition
- resistance training
- signaling pathway
- endoplasmic reticulum stress
- heart rate
- cell death
- patient reported outcomes