White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease: results from the Ontario Neurodegenerative Diseases Research Initiative.
Daniela Cristina Carvalho de AbreuFrederico Pieruccini-FariaYanina Sarquis-AdamsonAlanna BlackJulia FraserKaren Van OoteghemBenjamin CornishDavid GrimesMandar JogMario MasellisThomas SteevesNuwan NanayakkaraJoel RamirezChristopher ScottMelissa HolmesMiracle OzzoudeCourtney BerezukSean SymonsSeyyed Mohammad Hassan HaddadStephen R ArnottMalcolm BinnsStephen StrotherDerek BeatonKelly SunderlandAthena TheyersBrian TanMojdeh ZamyadiBrian LevineJoseph B OrangeAngela C RobertsWendy LouSujeevini SujanthanDavid P BreenConnie MarrasDonna KwanSabrina AdamoAlicia PeltschAngela K TroyerSandra E BlackPaula M McLaughlinAnthony E LangWilliam McIlroyRobert Barthanull nullManuel Montero-OdassoPublished in: European journal of neurology (2023)
White matter hyperintensity burden at baseline predicted cognitive but not motor decline in early to mid-stage PD. The motor decline observed after 2 years in these older adults with PD is probably related to the primary neurodegenerative process than comorbid white matter pathology.