Involvement of Multiple Variants of Soluble CD146 in Systemic Sclerosis: Identification of a Novel Profibrotic Factor.

Marie NolletRichard BachelierAhmad JoshkonWaël TraboulsiAmandine MahieuxAnais MoyonAlexandre MullerIndumathi SomasundaramStéphanie SimonciniFranck PeirettiAurélie S LeroyerBenjamin GuilletBrigitte GranelFrançoise Dignat-GeorgeNathalie BardinAlexandrine Foucault-BertaudMarcel Blot-Chabaud

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Variants of sCD146, and in particular the novel I5-13-sCD146 splice variant, could constitute novel biomarkers and/or molecular targets for the diagnosis and treatment of SSc and other angiogenesis- or fibrosis-related disorders.

Keyphrases

systemic sclerosis
interstitial lung disease
copy number
endothelial cells
vascular endothelial growth factor
rheumatoid arthritis
single molecule
nk cells
liver fibrosis