Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease.
Alexander J EhrenbergA K NguyP TheofilasS DunlopC K SuemotoA T Di Lorenzo AlhoR P LeiteR Diehl RodriguezM B MejiaU RübJ M FarfelRenata Eloah de Lucena Ferretti-RebustiniC F NascimentoR NitriniC A PasquallucciW Jacob-FilhoB MillerW W SeeleyH HeinsenL T GrinbergPublished in: Neuropathology and applied neurobiology (2017)
LC and DRN neurons exhibited ht-NCI during AD precortical stages. The ht-NCI increases along AD progression on both nuclei, but quantitative changes in LC precede DRN changes.