Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis.
Sungsin JoEun-Ju LeeBora NamJuyeon KangSeunghun LeeJeehee YounYe-Soo ParkYong-Gil KimTae Hwan KimPublished in: Arthritis research & therapy (2020)
Treatment with dutasteride affected the bone formation in the spine of curdlan-treated SKG mice, and DHT treatment attenuated osteoblast differentiation in vitro. Therefore, contrary to what could be expected if osteoblasts contributed to spinal ankylosis, DHT inhibition might increase rather than decrease the progression of spinal ankylosis despite the higher levels of DHT observed in many AS patients.
Keyphrases
- ankylosing spondylitis
- end stage renal disease
- newly diagnosed
- spinal cord
- induced apoptosis
- chronic kidney disease
- high fat diet induced
- type diabetes
- adipose tissue
- combination therapy
- disease activity
- cell proliferation
- skeletal muscle
- oxidative stress
- insulin resistance
- signaling pathway
- endoplasmic reticulum stress
- pi k akt