Hierarchical MOF@AuNP/Hairpin Nanotheranostic for Enhanced Photodynamic Therapy via O 2 Self-Supply and Cancer-Related MicroRNA Imaging In Vivo.
Chan YangShuo TianWeiyu QiuLiuting MoWeiying LinPublished in: Analytical chemistry (2023)
Developing a nanotheranostic with a high sensing performance and efficient therapy was significant in cancer diagnosis and treatment. Herein, a Au nanoparticle and hairpin-loaded photosensitive metal-organic framework (PMOF@AuNP/hairpin) nanotheranostic was constructed by growing AuNPs on PMOF in situ and then attaching hairpins. On the one hand, the PMOF@AuNP/hairpin nanotheranostic could effectively transfer O 2 into ROS, facilitating efficient PDT. Additionally, the nanotheranostic possessed catalase-like activity, which could effectively catalyze H 2 O 2 to generate O 2 , thus achieving O 2 -evolving PDT and significantly enhancing the antitumor effect of PDT in vivo. On the other hand, the nanotheranostic showed a high loading efficiency of hairpins and achieved the sensitive and selective detection of miR-21 both in living cells and in vivo. Moreover, the nanotheranostic could dynamically monitor the miR-21 level. Due to the excellent imaging performance, the nanotheranostic could recognize cancer cells and might provide important information on cancer progression for PDT. The developed PMOF@AuNP/hairpin nanotheranostic provided a useful tool for tumor diagnosis and antitumor therapy.
Keyphrases
- photodynamic therapy
- metal organic framework
- living cells
- cell proliferation
- fluorescence imaging
- high resolution
- long non coding rna
- papillary thyroid
- healthcare
- drug delivery
- fluorescent probe
- dna damage
- long noncoding rna
- squamous cell carcinoma
- squamous cell
- wastewater treatment
- mesenchymal stem cells
- single molecule
- mass spectrometry
- smoking cessation
- label free
- childhood cancer