BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells.
Tzu-Yu LinHsiu-Han ChanShang-Hung ChenSailu SarvagallaPai-Sheng ChenMohane Selvaraj CoumarSiao Muk ChengYung-Chieh ChangChun-Hui LinEuphemia Y LeungChun Hei Antonio CheungPublished in: Autophagy (2019)
ACTA1: actin; ATG: autophagy related; BIRC: baculoviral inhibitor of apoptosis repeat-containing; BAF: bafilomycin A1; CQ: chloroquine; CASP3: caspase 3; HSPB1/Hsp27: heat shock protein family B (small) member 1/heat shock protein 27; IAPs: inhibitors of apoptosis proteins; IP: immunoprecipitation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PLA: proximity ligation assay; SQSTM1/p62: sequestosome 1; siRNA: small interfering RNA.
Keyphrases
- heat shock protein
- cell death
- cell cycle arrest
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- dna damage
- diabetic rats
- heat shock
- endothelial cells
- high glucose
- simultaneous determination
- papillary thyroid
- cancer therapy
- signaling pathway
- pi k akt
- mass spectrometry
- dna repair
- high throughput
- liquid chromatography
- drug induced
- young adults
- high resolution mass spectrometry
- childhood cancer
- single cell
- heat stress