Irritable Bowel Syndrome Therapeutic Has Broad-Spectrum Antimicrobial Activity.
Ashley L CunninghamOrhi Esarte PalomeroBradley J VossM Stephen TrentBryan W DaviesPublished in: Antimicrobial agents and chemotherapy (2021)
Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here, we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. Our results suggest otilonium bromide acts on enteric pathogens and may offer a new scaffold for poorly absorbed intestinal antimicrobial therapy.
Keyphrases
- irritable bowel syndrome
- multidrug resistant
- gram negative
- escherichia coli
- staphylococcus aureus
- drug resistant
- skeletal muscle
- acinetobacter baumannii
- healthcare
- emergency department
- silver nanoparticles
- klebsiella pneumoniae
- anti inflammatory
- antimicrobial resistance
- stem cells
- pseudomonas aeruginosa
- cystic fibrosis