Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma.
Kristopher R BosseAnna Maria GiudiceMaria V LaneBrendan McIntyrePatrick M SchürchGuillem Pascual-PastoSamantha N BuongervinoSriyaa SureshAlana FitzsimmonsAdam HymanMaria Gemino-BorromeoJennifer SaggioEsther R BerkoAlexander A DanielsJennifer StundonMegan FriedrichsenXin LiuMatthew L MargolisMarilyn M LiMarni Brisson TiernoGeoffrey R OxnardJohn M MarisYael P MossePublished in: Cancer discovery (2022)
ctDNA is prevalent in children with neuroblastoma. Serial ctDNA profiling in patients with neuroblastoma improves the detection of potentially clinically actionable and functionally relevant variants in cancer driver genes and delineates dynamic tumor evolution and disease progression beyond that of standard tumor sequencing and clinical surveillance practices. See related commentary by Deubzer et al., p. 2727. This article is highlighted in the In This Issue feature, p. 2711.
Keyphrases
- circulating tumor
- cell free
- circulating tumor cells
- single cell
- genome wide
- copy number
- primary care
- healthcare
- papillary thyroid
- public health
- young adults
- dna methylation
- gene expression
- deep learning
- loop mediated isothermal amplification
- bioinformatics analysis
- label free
- lymph node metastasis
- genome wide analysis