A preliminary, observational study using whole-blood RNA sequencing reveals differential expression of inflammatory and bone markers post-implantation of percutaneous osseointegrated prostheses.
Andrew MillerSujee JeyapalinaJay AgarwalMitchell ManselJames Peter BeckPublished in: PloS one (2022)
Whole-blood RNA-seq data from 10 patients who previously underwent percutaneous osseointegrated lower limb implantation revealed four genes of interest that are known to be involved in inflammation or bone remodeling. If verified in future studies, these genes may serve as markers for predicting optimal bone remodeling and stomal tissue healing following OI device implantation.
Keyphrases
- single cell
- rna seq
- lower limb
- bone mineral density
- oxidative stress
- soft tissue
- bone loss
- minimally invasive
- ultrasound guided
- radiofrequency ablation
- genome wide identification
- bioinformatics analysis
- electronic health record
- big data
- current status
- body composition
- machine learning
- gene expression
- transcription factor
- deep learning