Adverse clinical outcomes associated with infections by Enterobacterales producing ESBL (ESBL-E): a systematic review and meta-analysis.

Weiping LingLuis Furuya-KanamoriYukiko EzurePatrick N A Harris David L Paterson

Published in: JAC-antimicrobial resistance (2021)

Infections by ESBL-E appear to be significantly associated with mortality but not septic shock. Available studies investigating bacteraemia and shock as an intermediate outcome of ESBL-E infections are lacking. Future studies investigating the relationship between clinical outcomes and molecular characteristics of resistant strains are further warranted, along with studies investigating this in non-bacteraemic patients.

Keyphrases

escherichia coli
klebsiella pneumoniae
septic shock
case control
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
multidrug resistant
risk factors
coronary artery disease
current status
patient reported outcomes
adverse drug
drug induced