Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis.

Mukundan AtturXin DuanLei CaiTianzhen HanWeili ZhangEric D TycksenJonathan SamuelsRobert H BrophySteven B AbramsonMuhammad Farooq Rai

Published in: Arthritis research & therapy (2021)

Postn deficiency protects against DMM-induced post-traumatic and age-related spontaneous OA. RNA-seq findings warrant further investigations to better understand the mechanistic role of Postn and its potential as a therapeutic target in OA.

Keyphrases

rna seq
knee osteoarthritis
single cell
high glucose
diabetic rats
rheumatoid arthritis
high fat diet induced
drug induced
type diabetes
endothelial cells
oxidative stress
replacement therapy
metabolic syndrome