Serum bicarbonate is associated with kidney outcomes in autosomal dominant polycystic kidney disease.
Charles J BlijdorpDavid SeversUsha M Musterd-BhaggoeRonald T GansevoortRobert ZietseEwout J Hoornnull nullPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)
In patients with ADPKD, a lower serum bicarbonate within the normal range predicts worse kidney outcomes independent of established prognostic factors for ADPKD and independent of urine ammonium excretion. Serum bicarbonate may add to prognostic models and should be explored as a treatment target in ADPKD.