Sirtuins in kidney health and disease.
Luca PericoGuiseppe RemuzziAriela BenigniPublished in: Nature reviews. Nephrology (2024)
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation. Furthermore, altered SIRT activity has been implicated in the pathophysiology and progression of acute and chronic kidney diseases, including acute kidney injury, diabetic kidney disease, chronic kidney disease, polycystic kidney disease, autoimmune diseases and renal ageing. The renoprotective roles of SIRTs in these diseases make them attractive therapeutic targets. A number of SIRT-activating compounds have shown beneficial effects in kidney disease models; however, further research is needed to identify novel SIRT-targeting strategies with the potential to treat and/or prevent the progression of kidney diseases and increase the average human healthspan.
Keyphrases
- oxidative stress
- dna repair
- dna damage
- ischemia reperfusion injury
- acute kidney injury
- chronic kidney disease
- diabetic rats
- induced apoptosis
- endothelial cells
- healthcare
- polycystic kidney disease
- signaling pathway
- liver failure
- type diabetes
- dna damage response
- drosophila melanogaster
- public health
- small molecule
- heat shock
- cell death
- drug induced
- risk assessment
- health information
- human health
- drug delivery
- endoplasmic reticulum stress
- hepatitis b virus
- extracorporeal membrane oxygenation
- social media
- climate change
- diabetic nephropathy
- mechanical ventilation
- induced pluripotent stem cells