First-Line Therapy for Nodal T-cell Non-Hodgkin Lymphomas: an Unmet Need in Hematology.
Vibor MilunovićInga Mandac SmoljanovićMartina Bogeljić PatekarViktor ZatezaloMarin KursarDelfa Radić-KrištoSlobodanka Ostojić KolonićSlavko GašparovPublished in: Current oncology reports (2023)
Current treatment with CHOP chemotherapy results in poor outcomes in the majority of patients. However, there are advances within the field. First breakthrough is the ECHELON-2 trial which showed that the addition of brentuximab vedotin improves outcomes in anaplastic large cell lymphoma. However, other types of peripheral T-cell non-Hodgkin lymphoma were underrepresented with optimal treatment not known. Second breakthrough is an increase of autologous stem cell transplantation usage in the first complete metabolic remission, except in ALK + anaplastic large cell lymphoma, offering better disease control. Despite advances in the field, CHOP remains the standard treatment for the majority of these lymphomas, but multiple trials are underway with the aim to improve this unmet need in hematology and, hopefully, leading us to a new era in the treatment of peripheral T-cell lymphomas.
Keyphrases
- diffuse large b cell lymphoma
- stem cell transplantation
- squamous cell carcinoma
- newly diagnosed
- bone marrow
- combination therapy
- cell therapy
- stem cells
- skeletal muscle
- lymph node
- mesenchymal stem cells
- systemic lupus erythematosus
- hodgkin lymphoma
- rheumatoid arthritis
- ejection fraction
- radiation therapy
- adipose tissue
- smoking cessation
- low dose
- disease activity
- neoadjuvant chemotherapy
- epidermal growth factor receptor