Pan-cancer landscape of CD274 (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression.
Richard S P HuangKarthikeyan MurugesanMeagan MontesionDean C PavlickDouglas A MataMatthew C HiemenzBrennan DeckerGarrett FramptonLee A AlbackerJeffrey S RossPublished in: Journal for immunotherapy of cancer (2022)
CD274 CN changes and PD-L1 expression were highly correlated in multiple tumor types. These prevalence data on CD274 CN changes across a large cohort of different solid tumors can be used to design future clinical studies to assess whether CD274 CN changes could be a potential biomarker for ICPI.