Visible-range hemi-indigo photoswitch: ON-OFF fluorescent binder for HIV-1 RNA.

Published in: Chemical communications (Cambridge, England) (2019)

A proof-of-principle for the application of hemi-indigo derivatives as RNA binders with photocontrollable fluorescence is presented. The photoswitch binds to the human immunodeficiency virus type 1 (HIV-1) RNA with a significant light-up effect. The fluorescence of the RNA-bound ligand can be reversibly switched ON and OFF by light without destroying the ligand-RNA associates.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
hepatitis c virus
hiv infected
hiv positive
hiv aids
nucleic acid
hiv testing
quantum dots
south africa
energy transfer