Development and Validation of a Quantitative LC-MS/MS Method for CDK4/6 Inhibitors Palbociclib, Ribociclib, Abemaciclib, and Abemaciclib-M2 in Human Plasma.
Sarah M BurkeMustafa KamalAndrew K L GoeyPublished in: Therapeutic drug monitoring (2023)
A sensitive liquid chromatography coupled with tandem mass spectrometry method to measure CDK4/6 inhibitors was developed and validated according to the Food and Drug Administration criteria. Quantitation of all analytes in clinical plasma samples confirmed that the assay is suitable for therapeutic drug monitoring and clinical pharmacokinetic studies of CDK4/6 inhibitors.
Keyphrases
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- simultaneous determination
- mass spectrometry
- high performance liquid chromatography
- high resolution mass spectrometry
- gas chromatography
- cell cycle
- solid phase extraction
- high resolution
- drug administration
- liquid chromatography tandem mass spectrometry
- cell proliferation
- ms ms
- climate change
- human health