Silver-based gels for oral and skin infections: antimicrobial effect and physicochemical stability.

Aim: To systematically evaluate the literature on silver (Ag) gels and their antimicrobial efficacy and physicochemical stability. Materials & methods: A search was performed in PubMed/MEDLINE, LILACS, Web of Science, Scopus, Embase and Google Scholar. Results: Gels were formulated with Ag nanoparticles, Ag oxynitrate and colloidal Ag and showed antimicrobial activity for concentrations ranging from 0.002 to 30%. Gels showed stability of their chemical components, and their physicochemical properties, including viscosity, organoleptic characteristics, homogeneity, pH and spreadability, were suitable for topical application. Conclusion: Ag-based gels show antimicrobial action proportional to concentration, with higher action against Gram-negative bacteria and physicochemical stability for oral and skin infection applications.