The predictive and prognostic value of weight loss and body composition prior to and during immune checkpoint inhibition in recurrent or metastatic head and neck cancer patients.
Anna C H WillemsenNina De MoorJeroen Van DesselLaura W J BaijensMichel BilaEsther HaubenMari F C M van den HoutVander Poorten VincentAnn HoebenPaul M J ClementAnnemie M W J ScholsPublished in: Cancer medicine (2022)
We conclude that the combination of cachexia at baseline and weight loss during ICI therapy is associated with worse OS in R/M HNSCC patients, independent of PD-L1 expression.
Keyphrases
- body composition
- weight loss
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- bariatric surgery
- squamous cell carcinoma
- peritoneal dialysis
- prognostic factors
- small cell lung cancer
- stem cells
- type diabetes
- body mass index
- roux en y gastric bypass
- adipose tissue
- patient reported outcomes
- cell therapy
- insulin resistance
- weight gain
- glycemic control