Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients.
Sukrutha ChettimadaDavid R LorenzVikas MisraSteven M WolinskyDana GabuzdaPublished in: BMC immunology (2020)
HIV-positive individuals on ART have increased abundance of circulating EVs carrying diverse small RNAs, with miRNAs being the most abundant. Several miRNAs associated with inflammation and oxidative stress are increased in circulating EVs of HIV-positive individuals, representing potential biomarkers of targetable pathways that contribute to disease pathogenesis.
Keyphrases
- hiv positive
- oxidative stress
- antiretroviral therapy
- men who have sex with men
- south africa
- hiv infected
- human immunodeficiency virus
- hiv testing
- end stage renal disease
- dna damage
- ischemia reperfusion injury
- hiv aids
- newly diagnosed
- diabetic rats
- induced apoptosis
- chronic kidney disease
- prognostic factors
- single cell
- genome wide
- hepatitis c virus
- peritoneal dialysis
- patient reported outcomes
- gene expression
- microbial community
- antibiotic resistance genes