Fragilides U-W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis.
Tung-Pin SuChien-Han YuanYi-Ming JhuBo-Rong PengZhi-Hong WenYu-Jen WuTung-Ying WuHong-Wen LiuPing-Jyun SungPublished in: Marine drugs (2019)
Three new 11,20-epoxybriaranes-fragilides U-W (1-3), as well as two known metabolites, junceellonoid D (4) and junceellin (5), were obtained from the octocoral Junceella fragilis. The structures of briaranes 1-3 were elucidated by spectroscopic methods and briaranes 3 and 5 displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7.