Evaluation of mutagenesis, necrosis and apoptosis induced by omeprazole in stomach cells of patients with gastritis.
Ana Maria Oliveira Ferreira da MataMarcia Fernanda Correia Jardim PazAg-Anne Pereira Melo de MenezesAntonielly Campinho Dos ReisBruna da Silva SouzaCarlos Dimas de Carvalho SousaSônia Alves MachadoThiago Soares Gondim MedeirosChandan SarkarMuhammad Torequl IslamJavad Sharifi RadSevgi Durna DaştanMohammed M AlshehriJoão Marcelo de Castro E SousaAna Amélia de Carvalho Melo CavalcantePublished in: Cancer cell international (2022)
The cytogenetic changescan be attributed to several mechanisms that are still unclear, including oxidative damage, as observed by increased catalase and superoxide dismutase expresion. Positive correlations between antioxidant enzymes were found with micronuclei formation, and were negative for picnoses. Thus, the continuous and prolonged omeprazole use induces genetic instability, which can be monitored through cytogenetic analyzes, as precursor for gastric cancer.