Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.
Daniel Araki RibeiroGlenda Nicioli da SilvaIngra Tais MalacarneLuciana Pellegrini PisaniDaisy Maria Favero SalvadoriPublished in: Pathophysiology : the official journal of the International Society for Pathophysiology (2024)
Obesity is a big public health problem that claims several thousand lives every year. Bariatric surgery has arisen as a suitable procedure for treating obesity, particularly morbid obesity. Oxidative stress, genotoxicity, apoptosis, and inflammatory responses are recognized as the most important occurrences in carcinogenesis, as they actively contribute to the multistep process. This study aimed to briefly review the connection between oxidative stress, genotoxicity, apoptosis, and inflammation in obese patients undergoing bariatric surgery, focusing on its impact on carcinogenesis. Regarding oxidative stress, bariatric surgery may inhibit the synthesis of reactive oxygen species. Moreover, a significant reduction in the inflammatory status after weight loss surgery was not observed. Bariatric surgery prevents apoptosis in several tissues, but the maintenance of low body weight for long periods is mandatory for mitigating DNA damage. In conclusion, the association between bariatric surgery and cancer risk is still premature. However, further studies are yet needed to elucidate the real association between bariatric surgery and a reduced risk of cancer.
Keyphrases
- bariatric surgery
- weight loss
- oxidative stress
- obese patients
- dna damage
- roux en y gastric bypass
- gastric bypass
- diabetic rats
- public health
- ischemia reperfusion injury
- induced apoptosis
- patients undergoing
- body weight
- glycemic control
- weight gain
- metabolic syndrome
- type diabetes
- insulin resistance
- cell death
- gene expression
- body mass index
- dna repair
- adipose tissue
- young adults
- machine learning
- coronary artery disease
- acute coronary syndrome
- cell cycle arrest
- signaling pathway
- skeletal muscle
- health insurance
- coronary artery bypass
- surgical site infection
- percutaneous coronary intervention