Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.

Gora DiopCéline DerboisCheikh LoucoubarBabacar MbengueBineta Niakhana NdaoFatou ThiamAlassane ThiamRokhaya NdiayeYakhya DieyeRobert OlasoJean-Francois DeleuzeAlioune Dieye

Published in: Malaria journal (2018)

In addition to the previously described association of +371G/C polymorphism in Ghanaians cohort, the RNASE3 +499G/C polymorphism was associated with susceptibility to SM in a Senegalese population. The haplotype +371G/+499G/+577T defined by RNASE3 polymorphisms was associated with severity. The genetic association identified independently in the Senegalese population provide additional evidence of a role of RNASE3 (ECP) in malaria severity.

Keyphrases

plasmodium falciparum
early onset
genome wide
gene expression
copy number