Cervical intraepithelial neoplasia in women with transformation zone type 3: cervical biopsy versus large loop excision.
Line Winther GustafsonAnne HammerMary Holten BennetsenChristina Blach KristensenHuda MajeedLone Kjeld PetersenBerit AndersenPinar BorPublished in: BJOG : an international journal of obstetrics and gynaecology (2022)
CIN2+ detection is underestimated in women aged ≥45 years with TZ3 if detection relies on the results of biopsies alone. To reduce the risk of underdiagnosis and overtreatment, future studies should explore the use of new biomarkers for risk stratification to improve discrimination between women at increased risk of CIN2+ who need to undergo LLETZ and women who may undergo follow-up.