Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits.

Xiaowei ZhangZhiwei ZhangYajuan YangYa SuoRuimeng LiuJiuchun QiuYungang ZhaoNing JiangChangle LiuGary TseGuangping LiTong Liu

Published in: Cardiovascular diabetology (2018)

The DPP-4 inhibitor alogliptin prevents cardiac diastolic dysfunction by inhibiting ventricular remodeling, explicable by improved mitochondrial function and increased mitochondrial biogenesis.

Keyphrases

left ventricular
oxidative stress
hypertrophic cardiomyopathy
heart failure
cardiac resynchronization therapy
acute myocardial infarction
aortic stenosis
left atrial
mitral valve
type diabetes
mouse model
signaling pathway
wound healing
acute coronary syndrome
ejection fraction
aortic valve