Safe use of proton pump inhibitors in patients with cirrhosis.

Rianne A WeersinkMargriet BoumaDavid Marinus Burger Joost Paulus Hubertus DrenthS Froukje Harkes-IdzingaNicole G M HunfeldHerold Johnny MetselaarMargje H Monster-SimonsSandra A W van PuttenKatka Taxis S D Sander Borgsteede

Published in: British journal of clinical pharmacology (2018)

We suggest using esomeprazole, omeprazole or rabeprazole in patients with CTP A or B cirrhosis and only esomeprazole in patients with CTP C. Pharmacokinetic changes are also important to consider when prescribing PPIs to vulnerable, cirrhotic patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
primary care
prognostic factors
emergency department
adverse drug
electronic health record