A novel patient-derived cell line of adrenocortical carcinoma shows a pathogenic role of germline MUTYH mutation and high tumour mutational burden.
Laura-Sophie LandwehrJochen SchreinerSilke AppenzellerStefan KircherSabine HerterichSilviu SbieraFassnacht MartinMatthias KroissIsabel WeigandPublished in: European journal of endocrinology (2021)
This model will be valuable as a pre-clinical ACC cell model with high TMB and a tool to study oxidative DNA damage in the adrenal gland.