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A novel patient-derived cell line of adrenocortical carcinoma shows a pathogenic role of germline MUTYH mutation and high tumour mutational burden.

Laura-Sophie LandwehrJochen SchreinerSilke AppenzellerStefan KircherSabine HerterichSilviu SbieraFassnacht MartinMatthias KroissIsabel Weigand
Published in: European journal of endocrinology (2021)
This model will be valuable as a pre-clinical ACC cell model with high TMB and a tool to study oxidative DNA damage in the adrenal gland.
Keyphrases
  • dna damage
  • dna repair
  • oxidative stress
  • single cell
  • cell therapy
  • stem cells
  • risk factors