Benefits of bone marrow mesenchymal stem cells compared to their conditioned medium in valproic acid-induced autism in rats.

Mehrazin Noshadian Iraj Ragerdi Kashani Reza Asadi-Golshan Davood Zarini Neda Ghafari Elham Zahedi Parichehr Pasbakhsh

Published in: Molecular biology reports (2024)

Post-developmental administration of BM-MSCs and BM-MSCs-CM can ameliorate prenatal neurodevelopmental deficits, restore cognitive and social behaviors, and modulate microglial and inflammatory markers. Results indicated that the improvement rate was higher in the BM-MSCs group than BM-MSCs-CM group.

Keyphrases

mesenchymal stem cells
umbilical cord
traumatic brain injury
autism spectrum disorder
pregnant women
inflammatory response
bone marrow
intellectual disability
mental health
lipopolysaccharide induced
spinal cord injury