A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk.

Etienne WeisskopfMonia Guidi Céline J Fischer Myriam Bickle-GrazEtienne BeaufilsKim An Nguyen Mathilde Morisod HarariSylvie RouillerSophie RothenburgerPascal GaucherandBehrouz Kassai Cristina Borradori TolsaManuella EpineyJean-François Tolsa Yvan Vial Jean-Michel Hascoët Olivier Claris Chin-Bin Eap Alice Panchaud Chantal Csajka

Published in: British journal of clinical pharmacology (2020)

The moderate between-subject variability in milk concentration of SCIT and the limited exposure to escitalopram through breast milk observed provide reassurance for treated mothers of breastfed healthy infants.

Keyphrases

end stage renal disease
newly diagnosed
major depressive disorder
ejection fraction
chronic kidney disease
bipolar disorder
pregnant women
peritoneal dialysis
prognostic factors
high intensity