Cortical excitability threshold can be increased by the AMPA blocker Perampanel in amyotrophic lateral sclerosis.

Björn E OskarssonElizabeth A MauricioJaimin S ShahZhuo LiMichael A Rogawski

Published in: Muscle & nerve (2021)

This study shows that perampanel effects the physiology of upper motor neurons. Studies aiming at gauging the effect of perampanel on ALS disease progression are already ongoing. Motor threshold may serve as a marker of biological target engagement.

Keyphrases

spinal cord
social media
transcranial direct current stimulation
spinal cord injury
amyotrophic lateral sclerosis
case control
angiotensin converting enzyme
angiotensin ii