Analgesic and Anti-Inflammatory Potential of the New Tetrahydropyran Derivative (2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) Methanol.
Gustavo Nunes de Santana CastroRaquel do Nascimento de SouzaAlba Cenélia Matos da SilvaRoberto Laureano-MeloWellington da Silva CôrtesSaulo Luis CapimMário Luiz Araujo de Almeida VasconcellosBruno Guimarães MarinhoPublished in: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2024)
In summary, the LS20 compound presented an antinociceptive effect, demonstrating the participation of the opioid system and an anti-inflammatory effect related to the inhibition of proinflammatory cytokine production. The compound also demonstrated safety at the cellular level.