Magnetic Resonance Imaging Parameters for Noninvasive Prediction of Epidermal Growth Factor Receptor Amplification in Isocitrate Dehydrogenase-Wild-Type Lower-Grade Gliomas: A Multicenter Study.
Yae Won ParkJie Eun ParkSung Soo AhnEui Hyun KimSeok-Gu KangJong Hee ChangSe Hoon KimSeung Hong ChoiHo Sung KimSeung-Koo LeePublished in: Neurosurgery (2021)
The presence of multifocal/multicentric distribution patterns, lower mean ADC, lower 5th percentile of ADC, and higher 95th percentile of nCBF may be useful imaging biomarkers for EGFR amplification in IDHwt LGGs. Moreover, quantitative imaging biomarkers may add value to qualitative imaging parameters.