Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model.

Junjie YeXiaodong SunQi JiangJianjun GuiShenglan FengBingqing QinLixia XieAi GuoJinju DongMing Sang

Published in: Journal of nanobiotechnology (2024)

Our study provides a comprehensive evaluation of UCB-Exos on the neuroprotective effects and suggests that inhibition of hyperphosphorylation of MAPK p38 and ERK 1/2 signaling pathways by regulating transcription levels of HspB1 and Ppef2 may be the key mechanism for UCB-Exos to improve PD-related pathological features.

Keyphrases

signaling pathway
umbilical cord
mesenchymal stem cells
pi k akt
mouse model
oxidative stress
epithelial mesenchymal transition
induced apoptosis
stem cells
transcription factor
cell proliferation
bone marrow
heat shock protein