Titanium implants have been widely used in bone tissue engineering for decades. However, orthopedic implant-associated infections increase the risk of implant failure and even lead to amputation in severe cases. Although TiO2 has photocatalytic activity to produce reactive oxygen species (ROS), the recombination of generated electrons and holes limits its antibacterial ability. Here, we describe a graphdiyne (GDY) composite TiO2 nanofiber that combats implant infections through enhanced photocatalysis and prolonged antibacterial ability. In addition, GDY-modified TiO2 nanofibers exert superior biocompatibility and osteoinductive abilities for cell adhesion and differentiation, thus contributing to the bone tissue regeneration process in drug-resistant bacteria-induced implant infection.
Keyphrases
- soft tissue
- visible light
- drug resistant
- reactive oxygen species
- tissue engineering
- quantum dots
- cell adhesion
- multidrug resistant
- dna damage
- stem cells
- silver nanoparticles
- bone mineral density
- reduced graphene oxide
- drug induced
- dna repair
- gold nanoparticles
- high glucose
- highly efficient
- essential oil
- diabetic rats
- cystic fibrosis
- postmenopausal women
- bone regeneration