The Preparation and Properties of Composite Hydrogels Based on Gelatin and (3-Aminopropyl) Trimethoxysilane Grafted Cellulose Nanocrystals Covalently Linked with Microbial Transglutaminase.
Shouwei ZhaoZhiwei ChenYaqi DongWenhui LuDeyi ZhuPublished in: Gels (Basel, Switzerland) (2022)
Mechanically enhanced gelatin-based composite hydrogels were developed in the presence of functionalized cellulose nanocrystals (CNCs) employing microbial transglutaminase (mTG) as a binding agent. In this work, the surfaces of CNCs were grafted with (3-Aminopropyl) trimethoxysilane with a NH 2 functional group, and the success of CNCs' modification was verified by FTIR spectroscopy and XPS. The higher degree of modification in CNCs resulted in more covalent cross-linking and dispersibility within the gelatin matrix; thus, the as-prepared hydrogels showed significantly improved mechanical properties and thermo-stability, as revealed by dynamic rheological analysis, uniaxial compression tests and SEM. The biocompatibility of the obtained hydrogels was evaluated by the MTT method, and it was found that the grafted CNCs had no obvious inhibitory effect on cell proliferation. Hence, the mechanically enhanced gelatin-based hydrogels might have great potential in biomedical applications.
Keyphrases
- hyaluronic acid
- tissue engineering
- drug delivery
- cell proliferation
- room temperature
- microbial community
- drug release
- extracellular matrix
- ionic liquid
- high resolution
- signaling pathway
- climate change
- silver nanoparticles
- candida albicans
- quantum dots
- biofilm formation
- risk assessment
- mass spectrometry
- staphylococcus aureus
- energy transfer
- cystic fibrosis
- aqueous solution