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Association of ADIPOQ Single-Nucleotide Polymorphisms with the Two Clinical Phenotypes Type 2 Diabetes Mellitus and Metabolic Syndrome in a Kinh Vietnamese Population.

Steven TruongNam Quang TranPhat Tung MaChi Khanh HoangBao Hoang LeThang DinhLuong TranThang Viet TranLinh Hoang Gia LeHoang Anh VuThao Phuong MaiMinh Duc Do
Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2022)
The results show that rs266729 is a lead candidate SNP associated with increased risk of developing T2DM and MetS in a Kinh Vietnamese population, while rs3774261 is associated with MetS only. Further functional characterization is needed to uncover the mechanism underlying the potential genotype-phenotype associations.
Keyphrases
  • metabolic syndrome
  • glycemic control
  • genome wide
  • insulin resistance
  • gene expression
  • type diabetes
  • skeletal muscle
  • dna methylation
  • climate change
  • human health
  • weight loss
  • genetic diversity