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Transcription and chromatin determinants of de novo DNA methylation timing in oocytes.

Lenka GahurovaShin-Ichi TomizawaSébastien A SmallwoodKathleen R Stewart-MorganHeba SaadehJeesun KimSimon R AndrewsTaiping ChenGavin Kelsey
Published in: Epigenetics & chromatin (2017)
These results do not support a major role for transcriptional transitions in the time of onset of DNA methylation in the oocyte, but suggest a model in which sequences least dependent on chromatin remodelling are the earliest to become permissive for methylation.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • transcription factor
  • dna damage
  • copy number
  • heat shock