Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.
Yibo FanYuan LiXiaodan YaoJiangkang JinAiling ScottBovey LiuShan WangLongfei HuoYing WangRuiping WangMelissa Pool PizziLang MaShan ShaoMatheus Sewastjanow-SilvaRebecca WatersDeyali ChatterjeeBin LiuNamita ShanbhagGuang PengGeorge Adrian CalinPawel Karol MazurSamir M HanashJo IshizawaYuki HirataOsamu NaganoZhenning WangLinghua WangWa XianFrank McKeonJaffer A AjaniShumei SongPublished in: Gut (2022)
T cell responses and modified macrophage function in GAC through the paracrine LIF factor. Cotargeting LIF/LIFR and CSF1R has great potential in targeting SOX9-mediated cancer stemness, T cell immunosuppression and metastases suggesting the novel combination therapy against advanced GAC.
Keyphrases
- combination therapy
- stem cells
- transcription factor
- papillary thyroid
- squamous cell carcinoma
- squamous cell
- cancer therapy
- epithelial mesenchymal transition
- adipose tissue
- locally advanced
- radiation therapy
- lymph node metastasis
- human health
- drug delivery
- risk assessment
- childhood cancer
- climate change
- cancer stem cells