Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.
Huub J van EykLinda D van SchinkelVasudev KantaeCharlotte E A DronkersJos J M WestenbergAlbert de RoosHildo J LambJ Wouter JukemaAmy C HarmsThomas HankemeierMario van der SteltIngrid M JazetPatrick C N RensenJohannes W A SmitPublished in: Nutrition & diabetes (2018)
Caloric restriction in T2D patients with CAD decreases AEA levels, but not 2-AG levels, which is paralleled by decreased lipid accumulation in adipose tissue, liver and heart, and improved cardiovascular function. Interestingly, baseline AEA levels strongly correlated with SAT volume. We anticipate that dietary interventions are worthwhile strategies in advanced T2D, and that reduction in AEA may contribute to the improved cardiometabolic phenotype induced by weight loss.