The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls.
R SeigerG GryglewskiM KlöblA KautzkyG M GodbersenL RischkaT VanicekM HienertJ UnterholznerLeo R SilberbauerP MichenthalerP HandschuhA HahnS KasperRupert LanzenbergerPublished in: The international journal of neuropsychopharmacology (2022)
Our investigation provides the first evidence, to our knowledge, that fast WM microstructure adaptations within 1 hour after i.v. SSRI administration precede elevations in mood due to SSRI treatment. These results add a new facet to the complex mode of action of antidepressant therapy. This study was registered at clinicaltrials.gov with the identifier NCT02711215.
Keyphrases
- major depressive disorder
- white matter
- bipolar disorder
- end stage renal disease
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- mechanical ventilation