Quantitative proteomic study reveals differential expression of matricellular proteins between fibrous dysplasia and cemento-ossifying fibroma pathogenesis.
Filipe Fideles Duarte-AndradeThaís Dos Santos Fontes PereiraJéssica Gardone VitórioMarina Gonçalves DinizLarissa Stefhanne Damasceno AmorimArkadiusz NawrockiLiza Figueiredo FelicoriLuiz Armando de MarcoCarolina Cavaliéri GomesMartin Rössel LarsenMarcella Nunes de Melo-BragaRicardo Santiago GomezPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
In summary, despite the morphological similarity between these diseases, our results demonstrated that COF and DF present numerous quantitative differences in their proteomic profiles. These findings suggest that these fibro-osseous lesions trigger distinct molecular mechanisms during their pathogenesis. Moreover, some proteins identified in our analysis could serve as potential biomarkers for differential diagnosis of these diseases after further validation.
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